What if you didn't need every pill to be real?
The Science
Open-label placebos have been clinically shown to improve outcomes — even when patients know they're taking them.
The Blend
Your bottle contains a custom mix of real and placebo capsules. You choose the ratio. We handle the rest.
The Ritual
Keep taking your nightly pill. Maintain the habit and mindset — just with fewer active ingredients over time.
How It Works
Choose your supplement
Start with melatonin, ashwagandha, or magnesium.
Pick your ratio
Decide how many active vs. placebo capsules you want.
We blend & ship
Your custom bottle arrives monthly, discreetly packaged.
Take one nightly
You'll never know which pill is which. That's the point.
The Taper
Wean off, don't quit cold turkey.
80 / 20
Mostly active
70 / 30
Building confidence
50 / 50
Half and half
30 / 70
Mostly ritual
10 / 90
Almost there
0 / 100
Pure ritual
PLACEBO Melatonin
50/50 Blend
60 capsules — 30 active (3mg melatonin) + 30 placebo.
Identical in appearance. Randomized in every bottle.
$24.99
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Ashwagandha
300mg KSM-66
Magnesium
200mg Glycinate
Vitamin D
2000 IU D3
The science is real.
Even when the pills aren't.
For decades, researchers assumed placebos only worked through deception — that patients had to believe they were receiving real treatment. That assumption was wrong.
A groundbreaking 2010 study at Harvard Medical School demonstrated that open-label placebos — placebos given with full disclosure — produced significant improvements in patients with Irritable Bowel Syndrome. Patients knew the pills contained no active ingredient, and they still got better.
“Placebos work even when you know they're placebos.”
Since then, research from institutions including the University of Sydney and multiple Harvard-affiliated labs has expanded on these findings. Open-label placebos have shown positive effects for chronic pain, cancer-related fatigue, allergic rhinitis, and even emotional distress.
The mechanism isn't fully understood, but leading theories point to conditioned responses, the therapeutic ritual of pill-taking, and the brain's ability to generate real physiological changes through expectation — even conscious expectation.
PLACEBO is built on this science. We're not asking you to believe in magic. We're asking you to trust the research — and your own biology.
Frequently Asked Questions
Correct. Half the capsules in each bottle are inert placebo pills with no active ingredient. But research shows that the ritual of taking a pill — even one you know is a placebo — can trigger real physiological responses. You're not paying for nothing. You're paying for a scientifically-backed system that helps you gradually reduce your dependence on supplements.
We're selling you a system, not just a supplement. The custom blending, randomization, and taper program are the product. Traditional supplement companies sell you a full dose forever — we help you need less over time. Think of it as paying for the off-ramp, not just the highway.
You don't — and that's by design. Every capsule in your bottle looks, feels, and weighs the same. They're randomized during manufacturing so there's no pattern to discover. This intentional uncertainty is what makes the open-label placebo effect work.
PLACEBO supplements are manufactured in an FDA-registered, GMP-certified facility. Like all dietary supplements, our products are regulated under DSHEA (Dietary Supplement Health and Education Act). The placebo capsules contain only inert, food-grade ingredients. We do not make any claims to treat, cure, or prevent any disease.
We're launching with Melatonin (3mg active dose) in a 50/50 blend. Ashwagandha (KSM-66), Magnesium Glycinate, and Vitamin D3 are in development and coming soon. Each supplement will offer customizable active-to-placebo ratios.
Yes. No contracts, no commitments, no guilt. You can pause, adjust your ratio, or cancel anytime from your account dashboard. We'll even tell you how to taper off our taper if you want — we're honest like that.
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